Development of Microporous Core-Shell Nanocomposites for Live Cell Applications (Proyecto PID2023-152844NB-I00 financiado por MCIN/ AEI /10.13039/501100011033/  y por FEDER Una manera de hacer Europa)

This proposal addresses the development of synthetic routes for constructing advanced microporous nanocomposites, specifically designed for use in biological contexts, such as therapeutic and diagnostic imaging applications. Herein, we will combine several nanocores made of Au, Pd or iron oxide with microporous shells based on either metal-organic frameworks (MOF) or covalent organic frameworks (COF). Selected nanocomposites, depending on the properties of the nanocores (plasmonic, magnetic, or catalytic), will be used as intracellular nanoreactors for stimuli responsive processes, including light, magnetic fields, and pro-drug activation (bioorthogonal decaging, or uncaging, chemistry). This project is focused on innovating and establishing new synthetic routes, with emphasis on demonstrating the prospective bioapplications of selected nanosystems at a proof-of-concept stage.