Revealing drug tolerant persister cells in cancer using contrast enhanced optical coherence and photoacoustic tomography (EU-H2020-ICT-2020-2, 101016964)

REAP project aims to develop imaging systems for detecting drug-tolerant persister cells across various scales. This includes a triple modal two-photon laser scanning – optical coherence – photoacoustic microscopy for in vitro studies and a dual modal optical coherence photoacoustic tomography for in vivo applications. Parallel developments in contrast agents based on biofunctionalized nanoparticles, new lasers, detector technology, and real-time data handling aided by deep learning-based analysis will contribute to the detection, characterization, and eventual eradication of therapy-resistant breast cancer. dual-modal.