DNA-Origami Nanosystems to modulate adaptive immunity (Proyecto PID2022-142338OB-I00 financiado por MCIN/ AEI /10.13039/501100011033/  y por FEDER Una manera de hacer Europa)

The aim of the project is to advance in the development of DNA-based functional nanomaterials for biological applications, with a clear focus on immunomodulatory aspects related to the physicochemical and biological features of the origamis. We are proposing the generation of a library of origami by varying geometries, sizes, and biomolecular surfaces to better understand and define how DNA origamis-based nanoparticles engage with specific cellular pathways based on recognition by immune cell receptors.